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L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer s disease-related cognitive decline McCaddon A; Hudson PRCNS Spectr 2010[Jan]; 15 (1 Suppl 1): 2-5; discussion 6Neuroinflammatory oxidative stress occurs early in AD pathology. Elevated blood Hcy is a useful marker for such neuroinflammation. Hcy contributes to pathological cascades involving AP and NFTs. In AD, Hcy should be lowered by B-vitamin supplements and NAC.|Acetylcysteine/*therapeutic use[MESH]|Alzheimer Disease/blood/cerebrospinal fluid/*complications/pathology[MESH]|Cognition Disorders/blood/cerebrospinal fluid/*drug therapy/*etiology[MESH]|Free Radical Scavengers/*therapeutic use[MESH]|Homocysteine/blood/cerebrospinal fluid[MESH]|Humans[MESH]|Oxidative Stress[MESH]|Plaque, Amyloid/pathology[MESH]|Tetrahydrofolates/*therapeutic use[MESH]|Vitamin B 12/*analogs & derivatives/therapeutic use[MESH]|Vitamin B Complex/therapeutic use[MESH] |
