Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Modifier-concept of colorectal carcinogenesis: lipidomics as a technical tool in pathway analysis Gassler N; Klaus C; Kaemmerer E; Reinartz AWorld J Gastroenterol 2010[Apr]; 16 (15): 1820-7In the modifier concept of intestinal carcinogenesis, lipids have been established as important variables and one focus is given to long-chain fatty acids. Increased consumption of long-chain fatty acids is in discussion to modify the development of colorectal carcinoma in humans. Saturated long-chain fatty acids, in particular, are assumed to promote carcinogenesis, whereas polyunsaturated forms are likely to act in the opposite way. At present, the molecular mechanisms behind these effects are not well understood. Recently, it has been demonstrated by lipidomics and associated molecular techniques, that activation and metabolic channeling of long-chain fatty acids are important mechanisms to modify colorectal carcinogenesis. In this Editorial, an overview about the present concept of long-chain fatty acids and its derivatives in colorectal carcinogenesis as well as technical algorithms in lipid analysis is given.|Acyl Coenzyme A/metabolism[MESH]|Apoptosis[MESH]|Carcinogens[MESH]|Colorectal Neoplasms/*metabolism[MESH]|Dietary Fats[MESH]|Disease Progression[MESH]|Fatty Acids/metabolism[MESH]|Humans[MESH]|Lipids/*chemistry[MESH]|Models, Biological[MESH]|Proteomics/methods[MESH] |