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lüll Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages Majdalawieh A; Ro HSMediators Inflamm 2010[]; 2010 (ä): 823821NF-kappaB comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-kappaB in inflammation and atherosclerosis and the regulation of the NF-kappaB signaling pathway are summarized. The structure, function, and regulation of the NF-kappaB inhibitors, IkappaBalpha and IkappaBbeta, are reviewed. The regulation of NF-kappaB activity by glucocorticoid receptor (GR) signaling and IkappaBalpha sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-kappaB transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-kappaB via physical interaction with IkappaBalpha and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified IkappaBalpha-interacting proteins play in NF-kappaB signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.|Amino Acid Sequence[MESH]|Animals[MESH]|Atherosclerosis/metabolism[MESH]|Carboxypeptidases/genetics/*metabolism[MESH]|Humans[MESH]|I-kappa B Proteins/genetics/*metabolism[MESH]|Inflammation/*metabolism[MESH]|Liver X Receptors[MESH]|Macrophages/immunology/*physiology[MESH]|Molecular Sequence Data[MESH]|NF-KappaB Inhibitor alpha[MESH]|NF-kappa B/chemistry/genetics/*metabolism[MESH]|Orphan Nuclear Receptors/metabolism[MESH]|PPAR gamma/metabolism[MESH]|Receptors, Glucocorticoid/metabolism[MESH]|Repressor Proteins/genetics/*metabolism[MESH]|Sequence Alignment[MESH]|Shock, Septic/physiopathology[MESH]|Signal Transduction/*physiology[MESH] |