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  lüll Receptor-interacting protein (RIP) kinase family Zhang D; Lin J; Han JCell Mol Immunol  2010[Jul]; 7 (4): 243-9Receptor-interacting protein (RIP) kinases are a group of threonine/serine  protein kinases with a relatively conserved kinase domain but distinct non-kinase  regions. A number of different domain structures, such as death and caspase  activation and recruitment domain (CARD) domains, were found in different RIP  family members, and these domains should be keys in determining the specific  function of each RIP kinase. It is known that RIP kinases participate in  different biological processes, including those in innate immunity, but their  downstream substrates are largely unknown. This review will give an overview of  the structures and functions of RIP family members, and an update of recent  progress in RIP kinase research.|*Multigene Family[MESH]|Animals[MESH]|Humans[MESH]|Protein Structure, Tertiary[MESH]|Receptor-Interacting Protein Serine-Threonine Kinases/chemistry/*metabolism[MESH]|Signal Transduction[MESH] |