Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll PTP1B: a double agent in metabolism and oncogenesis Yip SC; Saha S; Chernoff JTrends Biochem Sci 2010[Aug]; 35 (8): 442-9PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received renewed attention as an unexpected positive factor in tumorigenesis. Here, we highlight how views of this enzyme have evolved from regarding it as a simple metabolic off-switch to a more complex view of PTP1B as an enzyme that can play both negative and positive roles in diverse signaling pathways. These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer.|*Cell Transformation, Neoplastic[MESH]|*Molecular Targeted Therapy[MESH]|Animals[MESH]|Breast Neoplasms/drug therapy/*metabolism/pathology[MESH]|Diabetes Mellitus/drug therapy/*metabolism/pathology[MESH]|Humans[MESH]|Obesity/drug therapy/*metabolism/pathology[MESH]|Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism[MESH]|Signal Transduction/drug effects/physiology[MESH] |