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lüll Ionic mechanisms of central CO(2) chemosensitivity Chernov MM; Erlichman JS; Leiter JCRespir Physiol Neurobiol 2010[Oct]; 173 (3): 298-304A comparative analysis of chemosensory systems in invertebrates and vertebrates reveals that different animals use similar strategies when sensing CO(2) to control respiration. A variety of animals possess neurons that respond to changes in pH. These respiratory chemoreceptor neurons seem to rely largely on pH-dependent inhibition of potassium channels, but the channels do not appear to be uniquely adapted to detect pH. The 'chemosensory' potassium channels identified thus far are widely distributed, common potassium channels. The pH-sensitivity is a common feature of the channels whether the channels are in chemosensory neurons or not. Thus, the pattern of synaptic connectivity and the mix of potassium channels expressed seem to determine whether a neuron is chemosensory or not, rather than any special adaptation of a channel for pH-sensitivity. Moreover, there are often multiple pH-sensitive channels in each chemosensory neuron. These ionic mechanisms may, however, be only part of the chemosensory process, and pH-dependent modulation of synaptic activity seems to contribute to central chemosensitivity as well. In addition, the exploration of the mechanisms of pH-dependent modulation of ion channel activity in chemosensory cells is incomplete: additional mechanisms of pH modulation of channel activity may be found, and addition conductances, other than potassium channels, may participate in the chemosensory process.|*Respiratory Physiological Phenomena[MESH]|Animals[MESH]|Brain/cytology/*physiology[MESH]|Carbon Dioxide/*metabolism[MESH]|Chemoreceptor Cells/cytology/*metabolism[MESH]|Humans[MESH]|Hydrogen-Ion Concentration[MESH]|Ion Channels/*metabolism[MESH]|Neurons/cytology/metabolism[MESH] |