Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Oncoprotein metastasis and its suppression revisited Radulescu RTJ Exp Clin Cancer Res 2010[Apr]; 29 (1): 30The past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal cells with aberrant intrinsic properties in cancer pathophysiology. Aside from these insights, a novel concept termed "oncoprotein metastasis" (OPM) has recently been advanced and proposed to reflect protein-based neoplastic phenomena that might occur even before any modifications relating to the morphology, location or (epi)genetic outfit of cells during the malignant process. Here, evidence is presented that supports the OPM perception and thus should contribute not only to further rethink the definition of a normal cell, but also the treatment of cancer disease in the years to come.|*Gene Expression Regulation, Neoplastic[MESH]|Biophysics/methods[MESH]|Cell Transformation, Neoplastic/genetics/pathology[MESH]|Disease Progression[MESH]|Epigenesis, Genetic[MESH]|Humans[MESH]|Loss of Heterozygosity[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/metabolism/*pathology[MESH]|Oncogene Proteins/*metabolism[MESH]|Peptides/chemistry[MESH] |