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From the thymus to longevity in the periphery Wakim LM; Bevan MJCurr Opin Immunol 2010[Jun]; 22 (3): 274-8An important attribute of the adaptive immune system is the ability to remember a prior encounter with a pathogen; an ability termed immunological memory. Bigger, better, and stronger responses are mounted upon a secondary encounter with the pathogen potentially resulting in clearance of the infection before the development of disease. We will review recent advances in the field of memory CD8(+) T cell differentiation focusing on both intrinsic and extrinsic factors that govern the development of T cell memory.|*CD8-Positive T-Lymphocytes/cytology/immunology[MESH]|Animals[MESH]|Cell Differentiation/*immunology[MESH]|Humans[MESH]|Immunologic Memory/*immunology[MESH]|Lymphocyte Activation[MESH]|Mice[MESH]|Thymus Gland/cytology/*immunology[MESH] |
