suck pdf from google scholar
unlimited free pdf from europmc20373869    free
PDF from PMC    free
html from PMC    free
PDF vom PMID20373869  :  Publisher
PDF vom PMID20373869
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text


  • DeepDyve
  • Pubget Overpricing


  • lüll
  • Fatty acid synthase as a potential therapeutic target in cancer
  • Flavin R; Peluso S; Nguyen PL; Loda M
  • Future Oncol 2010[Apr]; 6 (4): 551-62
  • Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis. Overexpression of FASN is common in many cancers, and accumulating evidence suggests that it is a metabolic oncogene with an important role in tumor growth and survival, making it an attractive target for cancer therapy. Early small-molecule FASN inhibitors such as cerulenin, C75 and orlistat have been shown to induce apoptosis in several cancer cell lines and to induce tumor growth delay in several cancer xenograft models but their mechanism is still not well understood. These molecules suffer from pharmacological limitations and weight loss as a side effect that prevent their development as systemic drugs. Several potent inhibitors have recently been reported that may help to unravel and exploit the full potential of FASN as a target for cancer therapy in the near future. Furthermore, novel sources of FASN inhibitors, such as green tea and dietary soy, make both dietary manipulation and chemoprevention potential alternative modes of therapy in the future.
  • |Antineoplastic Agents/*therapeutic use[MESH]
  • |Enzyme Inhibitors/*therapeutic use[MESH]
  • |Fatty Acid Synthases/antagonists & inhibitors/*metabolism[MESH]
  • |Humans[MESH]
  • |Molecular Structure[MESH]
  • |Neoplasms/*drug therapy[MESH]





  • *{{pmid20373869}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=20373869 Fatty acid synthase as a potential therapeutic target in cancer ]</b> Future Oncol 2010; 6(4) ; 551-62 Flavin R; Peluso S; Nguyen PL; Loda M

        *20373869*

    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    Future Oncol

    551 4.6 2010