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lüll Structural dissection of cyclin dependent kinases regulation and protein recognition properties Lolli GCell Cycle 2010[Apr]; 9 (8): 1551-61Cyclin Dependent Kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. They are regulated by their cyclin partners and by a variety of additional protein effectors (inhibitors, kinases, phosphatases). Each CDK serves its function by means of specific protein recognition properties. These are also responsible for the differential regulation of CDKs/Cyclin couples involved in processes as different as cell cycle and transcription. The structural features determining general and specific properties for CDKs/Cyclin complexes are analyzed. They reside in an overall conserved architecture with divergent spots used by the complexes to present themselves to specific substrates or other protein effectors.|Binding Sites[MESH]|Cyclin-Dependent Kinases/*chemistry/metabolism[MESH]|Cyclins/chemistry/metabolism[MESH]|Protein Kinase Inhibitors/chemistry[MESH]|Protein Structure, Tertiary[MESH] |