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Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway Huang B; Yang XD; Lamb A; Chen LFCell Signal 2010[Sep]; 22 (9): 1282-90The eukaryotic transcription factor NF-kappaB regulates a wide range of host genes that control the inflammatory and immune responses, programmed cell death, cell proliferation and differentiation. The activation of NF-kappaB is tightly controlled both in the cytoplasm and in the nucleus. While the upstream cytoplasmic regulatory events for the activation of NF-kappaB are well studied, much less is known about the nuclear regulation of NF-kappaB. Emerging evidence suggests that NF-kappaB undergoes a variety of posttranslational modifications, and that these modifications play a key role in determining the duration and strength of NF-kappaB nuclear activity as well as its transcriptional output. Here we summarize the recent advances in our understanding of the posttranslational modifications of NF-kappaB, the interplay between the various modifications, and the physiological relevance of these modifications.|*Protein Processing, Post-Translational[MESH]|Animals[MESH]|Humans[MESH]|Inflammation/metabolism[MESH]|Mice[MESH]|NF-kappa B/metabolism[MESH]|Neoplasms/metabolism[MESH]|Signal Transduction[MESH]|Transcription Factor RelA/*metabolism[MESH] |
