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Robust and specific inhibition of microRNAs in Caenorhabditis elegans Kundu ST; Slack FJJ Biol 2010[]; 9 (3): 20MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo.|Animals[MESH]|Caenorhabditis elegans/*genetics[MESH]|Cell Differentiation/genetics[MESH]|Conserved Sequence[MESH]|Gene Expression Regulation/drug effects[MESH]|Genome, Helminth/drug effects[MESH]|Longevity/genetics[MESH]|MicroRNAs/analysis/*antagonists & inhibitors/metabolism/physiology[MESH]|Oligonucleotides, Antisense/pharmacology[MESH]|RNA, Small Interfering/*genetics[MESH] |
