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lüll Membrane associated Ca2+ buffers in the heart Lee D; Michalak MBMB Rep 2010[Mar]; 43 (3): 151-7Ca2+ is a universal signalling molecule that affects a variety of cellular processes including cardiac development. The majority of intracellular Ca2+ is stored in the endoplasmic and sarcoplasmic reticulum of muscle and non-muscle cells. Calreticulin is a well studied Ca2+-buffering protein in the endoplasmic reticulum, and calreticulin deficiency is embryonic lethal due to impaired cardiac development. Despite calsequestrin being the most abundant Ca2+-buffering protein in the sarcoplasmic reticulum, viability is maintained in embryos without calsequestrin and normal Ca2+ release and contractile function is observed. The Ca2+ homeostasis regulated by the endoplasmic and sarcoplasmic reticulum is critical for the development and proper function of the heart.|Buffers[MESH]|Calcium Signaling[MESH]|Calcium/*metabolism[MESH]|Calreticulin/metabolism[MESH]|Calsequestrin/metabolism[MESH]|Endoplasmic Reticulum/*metabolism[MESH]|Myocardium/*metabolism[MESH]|Sarcoplasmic Reticulum/metabolism[MESH] |