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lüll PC-TP/StARD2: Of membranes and metabolism Kang HW; Wei J; Cohen DETrends Endocrinol Metab 2010[Jul]; 21 (7): 449-56Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro. The structure of PC-TP comprises a hydrophobic pocket and a well-defined head group binding site, and its gene expression is regulated by peroxisome proliferator activated receptor-alpha. Recent studies have revealed key regulatory roles for PC-TP in lipid and glucose metabolism. Notably, Pctp(-/-) mice are sensitized to the action of insulin, and exhibit more efficient brown fat-mediated thermogenesis. PC-TP appears to limit access of fatty acids to mitochondria by stimulating the activity of thioesterase superfamily member 2, a newly characterized long-chain fatty acyl-coenzyme A thioesterase. Because PC-TP discriminates between phosphatidylcholines within lipid bilayers, it might function as a sensor that links metabolic regulation to membrane composition.|Adipose Tissue, Brown/*metabolism[MESH]|Animals[MESH]|Cell Membrane/metabolism[MESH]|Fatty Acids/metabolism[MESH]|Humans[MESH]|Mitochondria/metabolism[MESH]|PPAR alpha/metabolism[MESH]|Phosphatidylcholines/*metabolism[MESH]|Phospholipid Transfer Proteins/*metabolism[MESH]|Thermogenesis/physiology[MESH]|Thiolester Hydrolases/metabolism[MESH] |