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Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate Sauer K; Cooke MPNat Rev Immunol 2010[Apr]; 10 (4): 257-71The membrane lipid phosphatidylinositol-3,4,5-trisphosphate (PtdInsP(3)) regulates membrane receptor signalling in many cells, including immunoreceptor signalling. Here, we review recent data that have indicated essential roles for the soluble PtdInsP(3) analogue inositol-1,3,4,5-tetrakisphosphate (InsP(4)) in T cell, B cell and neutrophil development and function. Decreased InsP(4) production in leukocytes causes immunodeficiency in mice and might contribute to inflammatory vasculitis in Kawasaki disease in humans. InsP(4)-producing kinases could therefore provide attractive drug targets for inflammatory and infectious diseases.|Cell Differentiation/immunology[MESH]|Humans[MESH]|Immune System/*growth & development/*immunology[MESH]|Inositol Phosphates/*immunology[MESH]|Leukocytes/cytology/*immunology[MESH]|Signal Transduction/*immunology[MESH] |
