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From rabbit reticulocytes to clam oocytes: in search of the system that targets mitotic cyclins for degradation Hershko AMol Biol Cell 2010[May]; 21 (10): 1645-7By the late 1980s, the basic biochemistry of ubiquitin-mediated protein degradation had already been elucidated by studies that used reticulocyte lysates. However, the scope and biological functions of this system remained largely obscure. Therefore, I became interested at that time in the mechanisms by which mitotic cyclins are degraded in exit from mitosis. Using a cell-free system from clam oocytes that faithfully reproduced cell cycle stage-specific degradation of cyclins, we identified in 1995 a large ubiquitin ligase complex that targets mitotic cyclins for degradation. Subsequent studies in many laboratories showed that this ubiquitin ligase, now called the anaphase-promoting complex/cyclosome, has centrally important roles in many aspects of cell cycle control.|Anaphase-Promoting Complex-Cyclosome[MESH]|Animals[MESH]|Bivalvia/*metabolism[MESH]|Cell Cycle[MESH]|Cell-Free System/metabolism[MESH]|Cyclins/*history/*metabolism[MESH]|Female[MESH]|History, 20th Century[MESH]|History, 21st Century[MESH]|Israel[MESH]|Ligases/history/metabolism[MESH]|Mitosis[MESH]|Oocytes/cytology/metabolism[MESH]|Rabbits[MESH]|Reticulocytes/metabolism[MESH]|Ubiquitin-Protein Ligase Complexes[MESH]|Ubiquitin/history/metabolism[MESH] |
