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Pathophysiology & genetics of obstructive sleep apnoea Campana L; Eckert DJ; Patel SR; Malhotra AIndian J Med Res 2010[Feb]; 131 (ä): 176-87Obstructive sleep apnoea (OSA) is a highly prevalent condition with proven neurocognitive and cardiovascular consequences. OSA patients experience repetitive narrowing or collapse of the pharyngeal airway during sleep. Multiple factors likely underlie the pathophysiology of this condition with considerable inter-individual variation. Important risk factors for OSA include obesity, male gender, and ageing. However, the mechanisms underlying these major risk factors are not well understood. We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits.|Biomechanical Phenomena[MESH]|Cardiovascular Diseases[MESH]|Humans[MESH]|Lung/pathology[MESH]|Models, Biological[MESH]|Models, Genetic[MESH]|Respiration[MESH]|Respiratory System/pathology[MESH]|Risk Factors[MESH]|Sleep[MESH]|Sleep Apnea, Obstructive/*genetics/*physiopathology[MESH]|Time Factors[MESH] |
