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The population genetics of beneficial mutations Orr HAPhilos Trans R Soc Lond B Biol Sci 2010[Apr]; 365 (1544): 1195-201The population genetic study of advantageous mutations has lagged behind that of deleterious and neutral mutations. But over the past two decades, a number of significant developments, both theoretical and empirical, have occurred. Here, I review two of these developments: the attempt to determine the distribution of fitness effects among beneficial mutations and the attempt to determine their average dominance. Considering both theory and data, I conclude that, while considerable theoretical progress has been made, we still lack sufficient data to draw confident conclusions about the distribution of effects or the dominance of beneficial mutations.|*Genetic Fitness[MESH]|*Models, Genetic[MESH]|*Mutation[MESH]|Animals[MESH]|Drosophila[MESH]|Genetics, Population[MESH]|Selection, Genetic[MESH] |
