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From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones Lodish H; Flygare J; Chou SIUBMB Life 2010[Jul]; 62 (7): 492-6This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages.|*Erythropoiesis/drug effects[MESH]|Animals[MESH]|Cell Differentiation[MESH]|Cell Proliferation[MESH]|Erythroblasts[MESH]|Erythroid Precursor Cells/physiology[MESH]|Erythropoietin/physiology[MESH]|Glucocorticoids/physiology[MESH]|Hematopoietic Stem Cells/*cytology/*physiology[MESH]|Humans[MESH]|Stem Cell Factor/physiology[MESH] |
