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lüll Membrane-binding and enzymatic properties of RPE65 Kiser PD; Palczewski KProg Retin Eye Res 2010[Sep]; 29 (5): 428-42Regeneration of visual pigments is essential for sustained visual function. Although the requirement for non-photochemical regeneration of the visual chromophore, 11-cis-retinal, was recognized early on, it was only recently that the trans to cis retinoid isomerase activity required for this process was assigned to a specific protein, a microsomal membrane enzyme called RPE65. In this review, we outline progress that has been made in the functional characterization of RPE65. We then discuss general concepts related to protein-membrane interactions and the mechanism of the retinoid isomerization reaction and describe some of the important biochemical and structural features of RPE65 with respect to its membrane-binding and enzymatic properties.|Animals[MESH]|Carrier Proteins/*chemistry/metabolism[MESH]|Eye Proteins/*chemistry/metabolism[MESH]|Humans[MESH]|Leber Congenital Amaurosis/metabolism[MESH]|Protein Binding/physiology[MESH]|Retinal Pigment Epithelium/enzymology[MESH]|cis-trans-Isomerases[MESH] |