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Serum ferritin: Past, present and future Wang W; Knovich MA; Coffman LG; Torti FM; Torti SVBiochim Biophys Acta 2010[Aug]; 1800 (8): 760-9BACKGROUND: Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases. SCOPE OF REVIEW: In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool. MAJOR CONCLUSIONS: Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer. GENERAL SIGNIFICANCE: Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights.|Animals[MESH]|Biomedical Research/history/*trends[MESH]|Blood Proteins/physiology[MESH]|Extracellular Space/metabolism[MESH]|Ferritins/*blood/metabolism/*physiology[MESH]|Health Status[MESH]|History, 20th Century[MESH]|History, 21st Century[MESH]|Humans[MESH]|Iron Metabolism Disorders/complications/diagnosis/therapy[MESH] |
