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MicroRNA dysregulation in psychiatric disease Miller BH; Wahlestedt CBrain Res 2010[Jun]; 1338 (ä): 89-99MicroRNAs (miRNAs) are small regulatory RNAs that individually regulate up to several hundred genes, and collectively may regulate as much as two-thirds of the transcriptome. Recent evidence supports a role for miRNA dysregulation in psychiatric and neurological disorders, including schizophrenia, bipolar disorder, and autism. Small changes in miRNA expression can fine-tune the expression of multiple genes within a biological network, suggesting that miRNA dysregulation may underlie many of the molecular changes observed in psychiatric disease, and that therapeutic regulation of miRNA levels may represent a novel treatment option.|Animals[MESH]|Brain/metabolism[MESH]|Humans[MESH]|Mental Disorders/genetics/*metabolism[MESH]|MicroRNAs/*metabolism[MESH]|Models, Genetic[MESH]|Models, Neurological[MESH] |
