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Privileged scaffolds for library design and drug discovery Welsch ME; Snyder SA; Stockwell BRCurr Opin Chem Biol 2010[Jun]; 14 (3): 347-61This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.|*Models, Chemical[MESH]|Drug Delivery Systems/methods[MESH]|Drug Discovery/*methods[MESH]|Humans[MESH]|Pharmaceutical Preparations/chemistry[MESH]|Protein Binding[MESH]|Receptors, Cytoplasmic and Nuclear/chemistry/metabolism[MESH]|Small Molecule Libraries/chemical synthesis/*chemistry[MESH] |
