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lüll Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human Malik S; Bhaumik SRFEBS J 2010[Apr]; 277 (8): 1805-21The fourth lysine of histone H3 is post-translationally modified by a methyl group via the action of histone methyltransferase, and such a covalent modification is associated with transcriptionally active and/or repressed chromatin states. Thus, histone H3 lysine 4 methylation has a crucial role in maintaining normal cellular functions. In fact, misregulation of this covalent modification has been implicated in various types of cancer and other diseases. Therefore, a large number of studies over recent years have been directed towards histone H3 lysine 4 methylation and the enzymes involved in this covalent modification in eukaryotes ranging from yeast to human. These studies revealed a set of histone H3 lysine 4 methyltransferases with important cellular functions in different eukaryotes, as discussed here.|*Histone-Lysine N-Methyltransferase/genetics/metabolism[MESH]|Eukaryota/enzymology[MESH]|Histones/*metabolism[MESH]|Humans[MESH]|Lysine/*analogs & derivatives/metabolism[MESH]|Methylation[MESH]|Protein Processing, Post-Translational[MESH]|Saccharomyces cerevisiae Proteins/genetics[MESH]|Saccharomyces cerevisiae/genetics/metabolism[MESH]|Schizosaccharomyces pombe Proteins/genetics[MESH]|Schizosaccharomyces/genetics/metabolism[MESH]|Species Specificity[MESH] |