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Finding the middle ground: how kinetochores power chromosome congression Kops GJ; Saurin AT; Meraldi PCell Mol Life Sci 2010[Jul]; 67 (13): 2145-61Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.|Chromosome Segregation[MESH]|Chromosomes/*physiology[MESH]|Humans[MESH]|Kinetochores/*metabolism[MESH]|Metaphase[MESH]|Microtubules/metabolism[MESH]|Mitosis[MESH]|Spindle Apparatus/physiology[MESH] |
