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lüll Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy Kim DJ; Kim JH; Lim JS; Yu JS; Chung JJ; Kim MJ; Kim KWRadiographics 2010[Mar]; 30 (2): 503-16In patients with rectal cancer who have received concurrent chemotherapy and radiation therapy (CCRT) before surgery, magnetic resonance (MR) imaging has low accuracy in prediction of the pathologic stage owing to overstaging or understaging. The factors related to this problem include fibrosis, desmoplastic reaction, edema, inflammation, and viable tumor nets at a fibrotic scar from a previous tumor. Preoperative diagnosis with MR imaging of histologic variants of rectal adenocarcinoma, especially mucinous adenocarcinoma, is important because these variants tend to have a poor response to CCRT. In addition, these variants manifest with high signal intensity on T2-weighted images after CCRT; this finding makes it difficult to differentiate residual tumors from remaining mucin pools. MR volumetry and functional MR imaging may be helpful in prediction and assessment of tumor response to CCRT. Awareness of post-CCRT changes helps radiologists achieve appropriate restaging of irradiated rectal cancer with MR imaging and can lead to a reduction in understaging or overstaging. It is important to obtain and compare both pre- and post-CCRT images before interpreting the post-CCRT images.|*Chemotherapy, Adjuvant[MESH]|*Radiotherapy, Adjuvant[MESH]|Combined Modality Therapy[MESH]|Humans[MESH]|Magnetic Resonance Imaging/*methods[MESH]|Neoplasm Recurrence, Local/*diagnosis/*prevention & control[MESH]|Neoplasm Staging[MESH]|Rectal Neoplasms/*diagnosis/*therapy[MESH]|Treatment Outcome[MESH] |