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Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity Unger RH; Scherer PETrends Endocrinol Metab 2010[Jun]; 21 (6): 345-52Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.|Adipose Tissue/*metabolism/physiopathology[MESH]|Energy Intake/physiology[MESH]|Humans[MESH]|Hyperphagia/*complications/metabolism/physiopathology[MESH]|Leptin/blood/physiology[MESH]|Lipids/*adverse effects/blood[MESH]|Metabolic Syndrome/complications/*metabolism/physiopathology[MESH]|Obesity/*complications/metabolism/physiopathology[MESH] |
