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Profiling DNA methylomes from microarray to genome-scale sequencing Huang YW; Huang TH; Wang LSTechnol Cancer Res Treat 2010[Apr]; 9 (2): 139-47DNA cytosine methylation is a central epigenetic modification which plays critical roles in cellular processes including genome regulation, development and disease. Here, we review current and emerging microarray and next-generation sequencing based technologies that enhance our knowledge of DNA methylation profiling. Each methodology has limitations and their unique applications, and combinations of several modalities may help build the entire methylome. With advances on next-generation sequencing technologies, it is now possible to globally map the DNA cytosine methylation at single-base resolution, providing new insights into the regulation and dynamics of DNA methylation in genomes.|*Epigenesis, Genetic[MESH]|Animals[MESH]|DNA Methylation[MESH]|Humans[MESH]|Oligonucleotide Array Sequence Analysis/*methods[MESH] |
