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lüll Prostacyclin in the intensive care setting Ivy DDPediatr Crit Care Med 2010[Mar]; 11 (2 Suppl): S41-5The prostacyclins-prostanoids were one of the first medications used to treat pulmonary arterial hypertension (PAH). Three prostanoids have been developed to treat PAH: epoprostenol, treprostinil, and iloprost. In the acute setting, experience is growing, using the inhaled forms of these three medications. Inhalation may improve ventilation/perfusion matching, whereas in the intravenous form these medications may cause nonselective pulmonary vasodilation and may worsen ventilation/perfusion matching. Currently, there are no universal recommendations for dosing delivery of inhaled prostanoids to intubated patients in the intensive care unit setting.|*Critical Care[MESH]|Administration, Inhalation[MESH]|Antihypertensive Agents/administration & dosage/*therapeutic use[MESH]|Child[MESH]|Epoprostenol/administration & dosage/analogs & derivatives/therapeutic use[MESH]|Humans[MESH]|Hypertension, Pulmonary/*drug therapy[MESH]|Iloprost/administration & dosage/therapeutic use[MESH] |