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lüll SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis Ota H; Eto M; Ogawa S; Iijima K; Akishita M; Ouchi YJ Atheroscler Thromb 2010[May]; 17 (5): 431-5Sir2 (silent information regulator-2), an NAD(+)-dependent histone deacetylase, is highly conserved in organisms ranging from archaea to humans. Yeast Sir2 is responsible for silencing at repeated DNA sequences in mating-type loci, telomeres and rDNA, and plays critical roles in DNA repair, stress resistance and longevity.The phenomenon of human aging is known to be a critical cardiovascular risk factor. Senescence of endothelial cells has been proposed to be involved in vascular dysfunction and atherogenesis. Recent studies have demonstrated that mammalian Sirt1 NAD(+)-dependent protein deacetylase, the closest homologue of Sir2, regulates vascular angiogenesis, homeostasis and senescence. This review focuses on SIRT1 as a potential therapeutic target against atherosclerosis.|Aging/*physiology[MESH]|Animals[MESH]|Atherosclerosis/enzymology/*metabolism/physiopathology[MESH]|Cilostazol[MESH]|Homeostasis[MESH]|Humans[MESH]|Nitric Oxide Synthase Type III/*metabolism[MESH]|Oxidative Stress[MESH]|Sirtuin 1/*metabolism[MESH]|Tetrazoles/*pharmacology[MESH]|Up-Regulation[MESH] |