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Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV Elder JH; Lin YC; Fink E; Grant CKCurr HIV Res 2010[Jan]; 8 (1): 73-80FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.|*Disease Models, Animal[MESH]|*Immunodeficiency Virus, Feline/drug effects/genetics[MESH]|Animals[MESH]|Aspartic Acid Proteases/antagonists & inhibitors/drug effects[MESH]|Cats[MESH]|Drug Design[MESH]|Feline Acquired Immunodeficiency Syndrome/drug therapy/*virology[MESH]|Gene Products, gag[MESH]|Gene Products, pol[MESH]|HIV Infections/drug therapy/virology[MESH]|HIV/drug effects/genetics[MESH]|Humans[MESH]|Protease Inhibitors/chemistry[MESH]|Virus Replication[MESH] |
