Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment Ramirez J; Lukin K; Hagman JCurr Opin Immunol 2010[Apr]; 22 (2): 177-84The generation of B lymphocytes from hematopoietic progenitors requires lineage-specific transcription factors that progressively direct cell fate choices. Differentiation of hematopoietic stem cells to lymphoid progenitors requires Ikaros-dependent lineage priming and graded levels of PU.1, which are controlled by Ikaros and Gfi1. E2A drives expression of EBF1, which initiates B lineage specification. EBF1, in addition to Pax5, is necessary for commitment to the B cell lineage. As a model of gene activation in early B lymphopoiesis, mb-1 genes are activated sequentially by factors (e.g. EBF1) that initiate chromatin modifications before transcription. This review highlights the requisite interplay between transcription factors and epigenetic mechanisms in the context of B cell development.|*Cell Lineage[MESH]|*Lymphopoiesis[MESH]|Animals[MESH]|Antigens, Differentiation/genetics/immunology[MESH]|B-Lymphocytes/*immunology[MESH]|Epigenesis, Genetic/immunology[MESH]|Gene Expression Regulation, Developmental[MESH]|Hematopoietic Stem Cells/*immunology[MESH]|Humans[MESH]|Transcription Factors/*immunology[MESH] |