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lüll Bridging the gene-behavior divide through neuroimaging deletion syndromes: Velocardiofacial (22q11 2 Deletion) and Williams (7q11 23 Deletion) syndromes Eisenberg DP; Jabbi M; Berman KFNeuroimage 2010[Nov]; 53 (3): 857-69Investigating the relationship between genes and the neural substrates of complex human behavior promises to provide essential insight into the pathophysiology of mental disorders. One approach to this inquiry is through neuroimaging of individuals with microdeletion syndromes that manifest in specific neuropsychiatric phenotypes. Both Velocardiofacial syndrome (VCFS) and Williams syndrome (WS) involve haploinsufficiency of a relatively small set of identified genes on the one hand and association with distinct, clinically relevant behavioral and cognitive profiles on the other hand. In VCFS, there is a deletion in chromosomal region 22q11.2 and a resultant predilection toward psychosis, poor arithmetic proficiency, and low performance intelligence quotients. In WS, there is a deletion in chromosomal region 7q11.23 and a resultant predilection toward hypersociability, non-social anxiety, impaired visuospatial construction, and often intellectual impairment. Structural and functional neuroimaging studies have begun not only to map these well-defined genetic alterations to systems-level brain abnormalities, but also to identify relationships between neural phenotypes and particular genes within the critical deletion regions. Though neuroimaging of both VCFS and WS presents specific, formidable methodological challenges, including comparison subject selection and accounting for neuroanatomical and vascular anomalies in patients, and many questions remain, the literature to date on these syndromes, reviewed herein, constitutes a fruitful "bottom-up" approach to defining gene-brain relationships.|Brain Mapping/methods[MESH]|Brain/*physiopathology[MESH]|DiGeorge Syndrome/*genetics/*physiopathology[MESH]|Diagnostic Imaging/*methods[MESH]|Genotype[MESH]|Humans[MESH]|Phenotype[MESH]|Williams Syndrome/*genetics/*physiopathology[MESH] |