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NOD-like receptor (NLR) signaling beyond the inflammasome Shaw PJ; Lamkanfi M; Kanneganti TDEur J Immunol 2010[Mar]; 40 (3): 624-7Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.|Animals[MESH]|Humans[MESH]|Inflammation/*immunology[MESH]|Multiprotein Complexes/*immunology[MESH]|Nod Signaling Adaptor Proteins/*immunology[MESH]|Signal Transduction/*immunology[MESH] |
