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Vaccines and autoimmune diseases of the adult Orbach H; Agmon-Levin N; Zandman-Goddard GDiscov Med 2010[Feb]; 9 (45): 90-7Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review. Infrequently reported post-vaccination autoimmune diseases include systemic lupus erythematosus, rheumatoid arthritis, inflammatory myopathies, multiple sclerosis, Guillain-Barre syndrome, and vasculitis. In addition, we will discuss macrophagic myofasciitis, aluminum containing vaccines, and the recent evidence for autoimmunity following the use of human papillomavirus vaccine.|Adult[MESH]|Arthritis, Rheumatoid/etiology[MESH]|Autoimmune Diseases/*etiology/*therapy/virology[MESH]|Communicable Disease Control[MESH]|Communicable Diseases/virology[MESH]|Guillain-Barre Syndrome/etiology[MESH]|Humans[MESH]|Macrophages/metabolism[MESH]|Middle Aged[MESH]|Multiple Sclerosis/etiology[MESH]|Muscular Diseases/etiology[MESH]|Papillomaviridae/metabolism[MESH]|Papillomavirus Infections/prevention & control/virology[MESH]|Vaccines/*adverse effects/*therapeutic use[MESH]|Vasculitis/etiology[MESH] |
