Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis Bartok B; Firestein GSImmunol Rev 2010[Jan]; 233 (1): 233-55Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant therapeutic advances. The pathogenesis of RA is complex and includes many cell types, including T cells, B cells, and macrophages. Fibroblast-like synoviocytes (FLS) in the synovial intimal lining also play a key role by producing cytokines that perpetuate inflammation and proteases that contribute to cartilage destruction. Rheumatoid FLS develop a unique aggressive phenotype that increases invasiveness into the extracellular matrix and further exacerbates joint damage. Recent advances in understanding the biology of FLS, including their regulation regulate innate immune responses and activation of intracellular signaling mechanisms that control their behavior, provide novel insights into disease mechanisms. New agents that target FLS could potentially complement the current therapies without major deleterious effect on adaptive immune responses.|Adaptive Immunity[MESH]|Animals[MESH]|Apoptosis[MESH]|Arthritis, Rheumatoid/*immunology/pathology/therapy[MESH]|Cartilage, Articular/immunology/pathology[MESH]|Cytokines/immunology[MESH]|Fibroblasts/*immunology/pathology[MESH]|Humans[MESH]|Hyperplasia[MESH]|Immunity, Innate[MESH]|Inflammation Mediators/immunology[MESH]|Phenotype[MESH]|Signal Transduction/*immunology[MESH]|Synovial Membrane/*immunology/pathology[MESH] |