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Dowling-Degos disease Georgescu EF; Stanescu L; Popescu CF; Comanescu M; Georgescu IRom J Morphol Embryol 2010[]; 51 (1): 181-5Dowling-Degos disease (DDD) is a rare autosomal dominant inherited pigmentary disorder of the flexures with a reticulate aspect and with presence of prominent comedone-like lesions and pitted scars. The diagnosis includes acanthosis nigricans as well as other reticulate pigmentary disorders classified into: dyschromatrosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH) and reticulate acropigmentation of Kitamura (RAPK). We present a 35-year-old woman, which presented with flexural hyperpigmentation considerate as acanthosis nigricans. At a close clinical and histopathological examination, we obtained sure data for Dowling-Degos disease, with a possible familial history of this disease in her son. We review the literature data concerning this disease.|Adult[MESH]|Diagnosis, Differential[MESH]|Female[MESH]|Genetic Diseases, Inborn/diagnosis[MESH]|Humans[MESH]|Pigmentation Disorders/*diagnosis[MESH] |
