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lüll Analysis of tissue factor positive microparticles Key NSThromb Res 2010[Apr]; 125 Suppl 1 (Suppl 1): S42-5There has recently been intense interest in the clinical measurement of tissue factor (TF)-positive microparticles (MPs) in clinical disease states. This interest has been driven by the demonstration of an putative role for circulating TF-positive MPs in animal models of thrombus propagation. Both immunological and functional assays for MP-TF have been described. While each approach has its own advantages and drawbacks, neither has yet been truly established as the 'gold standard'. Heterogeneity of TF-bearing MPs, such as the variable co-expression of surface phosphatidylserine, may determine not only their procoagulant potential, but also additional properties including rate of clearance from the circulation.|Animals[MESH]|Biomarkers/metabolism[MESH]|Blood Coagulation[MESH]|Cell-Derived Microparticles/*metabolism[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Immune System[MESH]|Models, Biological[MESH]|Particle Size[MESH]|Phosphatidylserines/chemistry[MESH]|Thrombin/metabolism[MESH]|Thromboplastin/*metabolism[MESH]|Thrombosis/metabolism[MESH] |