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lüll Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications Tabit CE; Chung WB; Hamburg NM; Vita JARev Endocr Metab Disord 2010[Mar]; 11 (1): 61-74Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.|Animals[MESH]|Atherosclerosis/etiology/physiopathology[MESH]|Cardiovascular Diseases/*etiology[MESH]|Diabetes Mellitus/*physiopathology[MESH]|Endothelium, Vascular/*physiopathology[MESH]|Humans[MESH]|Inflammation/etiology/physiopathology[MESH]|Insulin Resistance/physiology[MESH]|Mitochondria/physiology[MESH]|Nitric Oxide Synthase Type III/physiology[MESH]|Nitric Oxide/biosynthesis/physiology[MESH]|Oxidative Stress[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH]|Protein Kinase C beta[MESH]|Protein Kinase C/metabolism[MESH]|Signal Transduction/physiology[MESH] |