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lüll Global regulation by the seven-component Pi signaling system Hsieh YJ; Wanner BLCurr Opin Microbiol 2010[Apr]; 13 (2): 198-203This review concerns how Escherichia coli detects environmental inorganic orthophosphate (P(i)) to regulate genes of the phosphate (Pho) regulon by the PhoR/PhoB two-component system (TCS). P(i) control by the PhoR/PhoB TCS is a paradigm of a bacterial signal transduction pathway in which occupancy of a cell surface receptor(s) controls gene expression in the cytoplasm. The P(i) signaling pathway requires seven proteins, all of which probably interact in a membrane-associated signaling complex. Our latest studies show that P(i) signaling involves three distinct processes, which appear to correspond to different states of the sensory histidine kinase PhoR: an inhibition state, an activation state, and a deactivation state. We describe a revised model for P(i) signal transduction of the E. coli Pho regulon.|*Gene Expression Regulation, Bacterial[MESH]|*Signal Transduction[MESH]|Bacterial Proteins/genetics/metabolism[MESH]|Escherichia coli Proteins/genetics/*metabolism[MESH]|Escherichia coli/genetics/*metabolism[MESH]|Phosphates/*metabolism[MESH]|Regulon[MESH] |