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lüll Adoptive T cell therapy of cancer Brenner MK; Heslop HECurr Opin Immunol 2010[Apr]; 22 (2): 251-7Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.|*Immunotherapy, Adoptive[MESH]|Animals[MESH]|Antigens, Neoplasm/immunology[MESH]|Gene Transfer Techniques[MESH]|Humans[MESH]|Neoplasms/immunology/*therapy[MESH]|Receptors, Antigen, T-Cell/genetics/*immunology[MESH]|T-Lymphocytes/*immunology/transplantation[MESH]|Transgenes/genetics/*immunology[MESH]|Tumor Escape[MESH] |