Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525

Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
  English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |   
lüll Heparin-induced thrombocytopenia Greinacher A; Althaus K; Krauel K; Selleng SHamostaseologie 2010[Jan]; 30 (1): 17-8, 20-8Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reaction associated with increased thrombotic risk. The most important antigens are located on platelet factor 4 (PF4)/heparin complexes. HIT is always caused by platelet-activating antibodies, but not all PF4/heparin-reactive antibodies cause HIT. Thus, tests have a high negative, but only a moderate, positive predictive value. Clinical suspicion of HIT requires cessation of heparin and substitution with an alternative anticoagulant. As these drugs have an increased bleeding risk, they should be used in therapeutic doses only if HIT is considered very likely. Avoiding/postponing coumarin is crucial in minimizing microthrombotic complications. Recent studies of HIT immunobiology suggest that HIT mimics immunity against repetitive antigens, as are relevant in microbial defense. Thus, understanding HIT may help unravel why host defenses can trigger autoimmunity.|Anticoagulants/*adverse effects[MESH]|Antiphospholipid Syndrome/blood[MESH]|Arterial Occlusive Diseases/blood/chemically induced[MESH]|Heparin/*adverse effects[MESH]|Humans[MESH]|Monitoring, Physiologic[MESH]|Platelet Count[MESH]|Predictive Value of Tests[MESH]|Renal Replacement Therapy[MESH]|Risk Factors[MESH]|Thrombocytopenia/blood/*chemically induced[MESH]|Venous Thrombosis/blood/chemically induced[MESH] |