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  • Vitamin D: newly discovered actions require reconsideration of physiologic requirements
  • Bikle DD
  • Trends Endocrinol Metab 2010[Jun]; 21 (6): 375-84
  • Vitamin D is not just for preventing rickets and osteomalacia. Recent findings in animal experiments, epidemiologic studies and clinical trials indicate that adequate vitamin D levels are important for cancer prevention, controlling hormone levels and regulating the immune response. Although 25 hydroxyvitamin D (25OHD) levels >10 ng/ml can prevent rickets and osteomalacia, these levels are not sufficient to provide these more recently discovered clinical benefits. Rather, levels of 25OHD >30 ng/ml are generally recommended. Determining optimal levels of 25OHD and the amount of vitamin D supplementation required to achieve those levels for the numerous actions of vitamin D will only be established with additional trials. In this review, these newer applications are summarized and therapeutic considerations are provided.
  • |Animals[MESH]
  • |Humans[MESH]
  • |Immune System/physiology[MESH]
  • |Receptors, Calcitriol/*physiology[MESH]
  • |Vitamin D Deficiency/*physiopathology[MESH]
  • |Vitamin D/*physiology[MESH]





  • *{{pmid20149679}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=20149679 Vitamin D: newly discovered actions require reconsideration of physiologic requirements ]</b> Trends Endocrinol Metab 2010; 21(6) ; 375-84 Bikle DD

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    Trends Endocrinol Metab

    375 6.21 2010