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lüll Vitamin D: newly discovered actions require reconsideration of physiologic requirements Bikle DDTrends Endocrinol Metab 2010[Jun]; 21 (6): 375-84Vitamin D is not just for preventing rickets and osteomalacia. Recent findings in animal experiments, epidemiologic studies and clinical trials indicate that adequate vitamin D levels are important for cancer prevention, controlling hormone levels and regulating the immune response. Although 25 hydroxyvitamin D (25OHD) levels >10 ng/ml can prevent rickets and osteomalacia, these levels are not sufficient to provide these more recently discovered clinical benefits. Rather, levels of 25OHD >30 ng/ml are generally recommended. Determining optimal levels of 25OHD and the amount of vitamin D supplementation required to achieve those levels for the numerous actions of vitamin D will only be established with additional trials. In this review, these newer applications are summarized and therapeutic considerations are provided.|Animals[MESH]|Humans[MESH]|Immune System/physiology[MESH]|Receptors, Calcitriol/*physiology[MESH]|Vitamin D Deficiency/*physiopathology[MESH]|Vitamin D/*physiology[MESH] |