Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Polo-box domain: a versatile mediator of polo-like kinase function Park JE; Soung NK; Johmura Y; Kang YH; Liao C; Lee KH; Park CH; Nicklaus MC; Lee KSCell Mol Life Sci 2010[Jun]; 67 (12): 1957-70Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo-box domain (PBD) present in the C-terminal non-catalytic region of polo kinases plays a pivotal role in the function of these enzymes. Recent advances in our comprehension of the mechanisms underlying mammalian polo-like kinase 1 (Plk1)-dependent protein-protein interactions revealed that the PBD serves as an essential molecular mediator that brings the kinase domain of Plk1 into proximity with its substrates, mainly through phospho-dependent interactions with its target proteins. In this review, current understanding of the structure and functions of PBD, mode of PBD-dependent interactions and substrate phosphorylation, and other phospho-independent functions of PBD are discussed.|Cell Cycle Proteins/*chemistry/metabolism[MESH]|Humans[MESH]|Phosphorylation[MESH]|Polo-Like Kinase 1[MESH]|Protein Kinases/*chemistry/metabolism[MESH]|Protein Serine-Threonine Kinases/*chemistry/metabolism[MESH]|Proto-Oncogene Proteins/*chemistry/metabolism[MESH] |