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Transcriptional switches: chemical approaches to gene regulation Lee LW; Mapp AKJ Biol Chem 2010[Apr]; 285 (15): 11033-8Given the role of transcriptional misregulation in the pathogenesis of human disease, there is enormous interest in the development of molecules that exogenously control transcription in a defined manner. The past decade has seen many exciting advancements in the identification of molecules that mimic or inhibit the interactions between natural transcriptional activators and their binding partners. In this minireview, we focus on four activator.target protein complexes, highlighting recent advances as well as challenges in the field.|*Gene Expression Regulation[MESH]|*Transcription, Genetic[MESH]|Amino Acid Motifs[MESH]|Animals[MESH]|Binding Sites[MESH]|Biochemistry/methods[MESH]|Cell Nucleus/metabolism[MESH]|DNA/chemistry[MESH]|Genes, p53[MESH]|Humans[MESH]|Kinetics[MESH]|Protein Structure, Tertiary[MESH]|Transcriptional Activation[MESH]|Tumor Suppressor Protein p53/metabolism[MESH]|p300-CBP Transcription Factors/metabolism[MESH] |
