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lüll The Cvt pathway as a model for selective autophagy Lynch-Day MA; Klionsky DJFEBS Lett 2010[Apr]; 584 (7): 1359-66Autophagy is a highly conserved, ubiquitous process that is responsible for the degradation of cytosolic components in response to starvation. Autophagy is generally considered to be non-selective; however, there are selective types of autophagy that use receptor and adaptor proteins to specifically isolate a cargo. One type of selective autophagy in yeast is the cytoplasm to vacuole targeting (Cvt) pathway. The Cvt pathway is responsible for the delivery of the hydrolase aminopeptidase I to the vacuole; as such, it is the only known biosynthetic pathway that utilizes the core machinery of autophagy. Nonetheless, it serves as a model for the study of selective autophagy in other organisms.|*Autophagy[MESH]|*Models, Biological[MESH]|*Signal Transduction[MESH]|Saccharomyces cerevisiae Proteins/metabolism[MESH]|Saccharomyces cerevisiae/*cytology/*metabolism[MESH] |