Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Memory CD8+ T cell differentiation Obar JJ; Lefrancois LAnn N Y Acad Sci 2010[Jan]; 1183 (ä): 251-66In response to infection or effective vaccination, naive antigen-specific CD8+ T cells undergo a dramatic highly orchestrated activation process. Initial encounter with an appropriately activated antigen-presenting cell leads to blastogenesis and an exponential increase in antigen-specific CD8+ T cell numbers. Simultaneously, a dynamic differentiation process occurs, resulting in formation of both primary effector and long-lived memory cells. Current findings have emphasized the heterogeneity of effector and memory cell populations with the description of multiple cellular subsets based on phenotype, function, and anatomic location. Yet, only recently have we begun to dissect the underlying factors mediating the temporal control of the development of distinct effector and memory CD8+ T cell sublineages. In this review we will focus on the requirements for mounting an effective CD8+ T cell response and highlight the elements regulating the differentiation of effector and memory subsets.|*Cell Differentiation/genetics/immunology[MESH]|Animals[MESH]|CD8-Positive T-Lymphocytes/metabolism/*physiology[MESH]|Gene Expression Regulation/immunology[MESH]|Humans[MESH]|Immunologic Memory/genetics/*immunology/physiology[MESH]|L-Selectin/genetics/metabolism[MESH]|Lymphocyte Activation/genetics/physiology[MESH]|Models, Biological[MESH]|T-Lymphocyte Subsets/immunology/metabolism/physiology[MESH] |