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lüll New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression Steward-Tharp SM; Song YJ; Siegel RM; O'Shea JJAnn N Y Acad Sci 2010[Jan]; 1183 (ä): 123-48T cell-directed therapies have become mainstays in the management of various autoimmune diseases and organ transplantation. The understanding of T cell biology has expanded greatly since the development of most agents currently in use. Here we discuss important recent discoveries pertaining to T helper cell differentiation, lineage commitment, and function. Within this context, we examine existing T cell-directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets.|*Drug Delivery Systems/methods[MESH]|Animals[MESH]|Autoimmune Diseases/immunology/*therapy[MESH]|Autoimmunity/immunology[MESH]|Humans[MESH]|Immunomodulation/*physiology[MESH]|Immunosuppression Therapy/*methods[MESH]|Immunosuppressive Agents/administration & dosage/chemical synthesis/therapeutic use[MESH]|Inflammation/immunology/*therapy[MESH]|Models, Biological[MESH]|T-Lymphocytes/drug effects/immunology/*physiology[MESH] |