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lüll SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions Detre C; Keszei M; Romero X; Tsokos GC; Terhorst CSemin Immunopathol 2010[Jun]; 32 (2): 157-71One or more of the signaling lymphocytic activation molecule (SLAM) family (SLAMF) of cell surface receptors, which consists of nine transmembrane proteins, i.e., SLAMF1-9, are expressed on most hematopoietic cells. While most SLAMF receptors serve as self-ligands, SLAMF2 and SLAMF4 use each other as counter structures. Six of the receptors carry one or more copies of a unique intracellular tyrosine-based switch motif, which has high affinity for the single SH2-domain signaling molecules SLAM-associated protein and EAT-2. Whereas SLAMF receptors are costimulatory molecules on the surface of CD4+, CD8+, and natural killer (NK) T cells, they also involved in early phases of lineage commitment during hematopoiesis. SLAMF receptors regulate T lymphocyte development and function and modulate lytic activity, cytokine production, and major histocompatibility complex-independent cell inhibition of NK cells. Furthermore, they modulate B cell activation and memory generation, neutrophil, dendritic cell, macrophage and eosinophil function, and platelet aggregation. In this review, we will discuss the role of SLAM receptors and their adapters in T cell function, and we will examine the role of these receptors and their adapters in X-linked lymphoproliferative disease and their contribution to disease susceptibility in systemic lupus erythematosus.|Animals[MESH]|Antigens, CD/genetics/*immunology/metabolism[MESH]|Cell Differentiation/immunology[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/genetics/*immunology/metabolism[MESH]|Lupus Erythematosus, Systemic/genetics/immunology[MESH]|Lymphocyte Activation/genetics/immunology[MESH]|Lymphoproliferative Disorders/genetics/immunology[MESH]|Receptors, Cell Surface/genetics/*immunology/metabolism[MESH]|Signaling Lymphocytic Activation Molecule Associated Protein[MESH]|Signaling Lymphocytic Activation Molecule Family Member 1[MESH]|T-Lymphocytes/cytology/*immunology/metabolism[MESH] |