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lüll Indoleamine 2,3-dioxygenase in tumor induced tolerance Liu XQ; Wang XChin Med J (Engl) 2009[Dec]; 122 (24): 3072-7OBJECTIVE: To review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance. DATA SOURCES: Published articles (1978 - 2009) on IDO and tumor induced tolerance were selected from Medline. STUDY SELECTION: Articles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose. RESULTS: Recent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells. CONCLUSION: Up-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role.|Animals[MESH]|Gene Expression Regulation, Neoplastic/physiology[MESH]|Humans[MESH]|Immune Tolerance/*physiology[MESH]|Indoleamine-Pyrrole 2,3,-Dioxygenase/*metabolism[MESH]|Neoplasms/*enzymology/*immunology[MESH] |